Aging comes at these two different ages, and this is how science explains it.

Some people have reported experiencing a sudden drop in health As the years go by, they say they feel like their bodies seem to suddenly deteriorate. However, a recent scientific study offers a possible explanation for this phenomenon: The concentrations of different molecules and microorganisms in the body can change dramatically during these two different ages: 44 and 60 years old.

The researchers examined a variety of molecules in people aged 25 to 75, as well as their microbiomes—the collections of bacteria, viruses, and fungi found in the body and on the skin. The study found that most of this abundance does not change gradually and temporally over time.

In contrast, there are two periods of rapid change throughout life, between the ages of 44 and 60, say scientists from Stanford University who published their study in the journal Nature's aging.

“It's not just that we change gradually over time, there are really radical changes. The mid-40s turned out to be a time of radical change, just like the early 60s.” Michael Snyder, who said this could potentially have health implications for him, said.

Analysis of molecules linked to cardiovascular disease revealed significant differences at both moments of life.In addition, molecules associated with immune function underwent specific changes in people in their 60s, according to a statement from Stanford University School of Medicine.

What does the data say about changes in aging?

The researchers analyzed data from 108 individuals to delve deeper into the biology of aging. Among their findings, they identified four different types of aging, or “age patterns,” which Reveals how different organs and systems age at different rates in each person.

The biological samples were analyzed periodically, and thousands of different molecules, such as RNA, proteins, and metabolites, were monitored, as well as changes in the participants’ microbiomes. Both molecules and microorganisms were found to experience variations in their quantities, increasing or decreasing over time. About 81% of the molecules examined showed nonlinear fluctuations in their number, suggesting that their levels changed more markedly at certain ages, specifically around 44 and 60 years.

That so many dramatic changes occur in the early 60s should come as no surprise, Snyder says, because it's well known that during this stage of life the risks associated with diseases and other phenomena associated with aging increase dramatically.

This is how changes happen in your mid-40s.

The number of changes that occurred in the mid-40s was surprisingly significant. Initially, scientists thought that menopause or perimenopause might be behind these profound changes in women, which skewed the study results. Studying By focusing exclusively on the women's group. However, By dividing the study group by gender, it was found that men around the age of 40 also experienced relevant changes.

“This suggests that while menopause or perimenopause may contribute to the changes that occur in women in their 40s, there are likely other, more important factors that affect both men and women. Identifying and studying these factors should be a priority,” says Xiaotao Chen, now at Nanyang Technological University in Singapore.

In people aged 40 years and older, significant changes were observed in the number of molecules associated with alcohol, caffeine, lipid metabolism, cardiovascular disease, skin and muscle.

In those aged 60 years, changes were associated with carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular disease, skin and muscle.

According to Snyder. Some of these changes may be related to lifestyle or behavioral factors, rather than biological factors.For example, alcohol metabolism disorders can result from increased alcohol consumption in the mid-40s, a period of life that is often stressful.

The team plans to study the reasons for these changes. But, whatever they may be, the need for this is Health care, The authors warn against this, especially between the ages of 40 and 60.

For example, increasing exercise to protect the heart and maintain muscle mass or reducing alcohol consumption at age 40, when the ability to metabolize it slows down.

*With information from EFE

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